ABSTRACT
Since the National Institute of the United States proposed the first Helicobacter pylori(Hp)eradication indication, peptic ulcer,in 1994, the indications of Hp eradication has been modified and expanded continuously.In 2015, Kyoto global consensus report on Helicobacter pylori gastritis proposed that “H. pylori-infected individuals should be offered eradication therapy, unless there are competing considerations”, which means that Hp eradication indications are no longer needed. This article aims to elaborate the evolution process of Hp eradication indications in China based on the five Chinese consensus reports of Hp infection treatment, and provide an outlook of the indications in the future.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of the continuous light force to the donor teeth on the periodontal healing after transplantation.</p><p><b>METHODS</b>Thirty-two maxillary and mandibular incisors in four 10-month-old male Beagle dogs were autotransplanted. The pulps were removed in all teeth. The teeth were divided into four groups, one control and three experimental groups. In control group (group 1), the teeth were unloaded. In the other three experimental groups, continuous force (0.49 N) was applied in the 1st (group 2), 2nd (group 3) and 4th (group 4) week, respectively. The dogs were sacrificed in the 8th week. The tissue blocks were demineralized and sectioned perpendicular to the long axis of the teeth. The histological analysis was made.</p><p><b>RESULTS</b>Histomophometric analysis revealed a significantly lower occurrence of replacement root resorption in the group 3 (2.1%) than in the control group (12.5%, P < 0.05). The significant lower incidence of replacement root resorption, and a higher surface and inflammatory root resorption were found in group 2 (6.3% and 68.8%) than in the control group (12.5% and 41.7%, P < 0.05). No significant difference was found between group 4 and control group (P > 0.05).</p><p><b>CONCLUSIONS</b>The orthodontic force promoted the regeneration of the periodontal ligament and prevented dentoalveolar ankylosis, whereas excessive initial force might cause root and bone resorption.</p>
Subject(s)
Animals , Dogs , Male , Incisor , Transplantation , Orthodontic Extrusion , Periodontal Ligament , Physiology , Root Resorption , Tooth Replantation , Transplantation, Autologous , Wound HealingABSTRACT
<p><b>OBJECTIVE</b>To observe the microstructure changes of rat alveolar bone around tooth root under orthodontic force loading.</p><p><b>METHODS</b>Ten 10-week-old rats were included in the study. Upper first molars were moved mesially with 0.196 N of force. The alveolar bone around the root of upper first molar was scanned by a micro-computed tomography scan system (SkyScan-1076) in different period after the initiation of orthodontic force loading (on the 3rd, 7th, 14th day after force loading) and analyzed by a specially-designed software to measure the microstructure parameters of alveolar bone (bone volume fraction, bone surface to volume ratio, structure model index, trabecular thickness, trabecular separation, trabecular number).</p><p><b>RESULTS</b>From the 7th day, bone volume fraction [(41 ± 14)%], structure model index (1.51 ± 0.52) and trabecular separation [(90 ± 30) µm] changed significantly in the compressive area compared with those [(64 ± 15)%, (0.51 ± 0.85), (56 ± 10) µm] on the 3rd day. From the 14th day, bone volume fraction [(78 ± 14)%], structure model index (0.28 ± 0.20) and trabecular separation [(29 ± 13) µm] changed significantly in the tension area compared with those [(67 ± 14)%, (0.40 ± 0.41), (48 ± 15) µm] on the 7th day. No difference on trabecular number was found between the compressive area and tension area (P > 0.05).</p><p><b>CONCLUSIONS</b>The significant resorption of the alveolar bone was observed on the 7th days in the compressive area and the deposition of the alveolar bone was observed on the 14th day in the compressive area after orthodontic force loading.</p>